Prediction of Protein-Protein Interface Sequence Diversity Using Flexible Backbone Computational Protein Design
نویسندگان
چکیده
منابع مشابه
Recapitulation of protein family divergence using flexible backbone protein design.
We use flexible backbone protein design to explore the sequence and structure neighborhoods of naturally occurring proteins. The method samples sequence and structure space in the vicinity of a known sequence and structure by alternately optimizing the sequence for a fixed protein backbone using rotamer based sequence search, and optimizing the backbone for a fixed amino acid sequence using ato...
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ژورنال
عنوان ژورنال: Structure
سال: 2008
ISSN: 0969-2126
DOI: 10.1016/j.str.2008.09.012